Cell Autonomous and Non-autonomous Effects of Senescent Cells in the Skin

Human and mouse skin accumulate senescent cells in both the epidermis and dermis during aging. When chronically present, senescent cells are thought to enhance the age-dependent deterioration of the skin during extrinsic and intrinsic aging. However, when transiently present, senescent cells promote...

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Detalles Bibliográficos
Autores principales: Demaria, Marco, Desprez, Pierre Yves, Campisi, Judith, Velarde, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466004/
https://www.ncbi.nlm.nih.gov/pubmed/25855157
http://dx.doi.org/10.1038/jid.2015.108
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author Demaria, Marco
Desprez, Pierre Yves
Campisi, Judith
Velarde, Michael C.
author_facet Demaria, Marco
Desprez, Pierre Yves
Campisi, Judith
Velarde, Michael C.
author_sort Demaria, Marco
collection PubMed
description Human and mouse skin accumulate senescent cells in both the epidermis and dermis during aging. When chronically present, senescent cells are thought to enhance the age-dependent deterioration of the skin during extrinsic and intrinsic aging. However, when transiently present, senescent cells promote optimal wound healing. Here, we review recent studies on how senescent cells and the senescence-associated secretory phenotype (SASP) contribute to different physiological and pathophysiological conditions in the skin with a focus on some of the cell autonomous and non-autonomous functions of senescent cells in the context of skin aging and wound healing.
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spelling pubmed-44660042016-01-01 Cell Autonomous and Non-autonomous Effects of Senescent Cells in the Skin Demaria, Marco Desprez, Pierre Yves Campisi, Judith Velarde, Michael C. J Invest Dermatol Article Human and mouse skin accumulate senescent cells in both the epidermis and dermis during aging. When chronically present, senescent cells are thought to enhance the age-dependent deterioration of the skin during extrinsic and intrinsic aging. However, when transiently present, senescent cells promote optimal wound healing. Here, we review recent studies on how senescent cells and the senescence-associated secretory phenotype (SASP) contribute to different physiological and pathophysiological conditions in the skin with a focus on some of the cell autonomous and non-autonomous functions of senescent cells in the context of skin aging and wound healing. 2015-04-09 2015-07 /pmc/articles/PMC4466004/ /pubmed/25855157 http://dx.doi.org/10.1038/jid.2015.108 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Demaria, Marco
Desprez, Pierre Yves
Campisi, Judith
Velarde, Michael C.
Cell Autonomous and Non-autonomous Effects of Senescent Cells in the Skin
title Cell Autonomous and Non-autonomous Effects of Senescent Cells in the Skin
title_full Cell Autonomous and Non-autonomous Effects of Senescent Cells in the Skin
title_fullStr Cell Autonomous and Non-autonomous Effects of Senescent Cells in the Skin
title_full_unstemmed Cell Autonomous and Non-autonomous Effects of Senescent Cells in the Skin
title_short Cell Autonomous and Non-autonomous Effects of Senescent Cells in the Skin
title_sort cell autonomous and non-autonomous effects of senescent cells in the skin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466004/
https://www.ncbi.nlm.nih.gov/pubmed/25855157
http://dx.doi.org/10.1038/jid.2015.108
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