NFκB-regulation of c-FLIP promotes TNFα-mediated RAF inhibitor resistance in melanoma

Targeted inhibitors elicit heterogeneous clinical responses in genetically stratified groups of patients. While most studies focus on tumor intrinsic properties, factors in the tumor microenvironment were recently found to modulate the response to inhibitors. Here, we show that in cutaneous BRAF V60...

Descripción completa

Detalles Bibliográficos
Autores principales: Shao, Yongping, Le, Kaitlyn, Cheng, Hanyin, Aplin, Andrew E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466037/
https://www.ncbi.nlm.nih.gov/pubmed/25751672
http://dx.doi.org/10.1038/jid.2015.91

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466037/
https://www.ncbi.nlm.nih.gov/pubmed/25751672
http://dx.doi.org/10.1038/jid.2015.91

Ejemplares similares