Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity

A series of doubly flexible nucleoside analogues were designed based on the acyclic sugar scaffold of acyclovir and the flex-base moiety found in the fleximers. The target compounds were evaluated for their antiviral potential and found to inhibit several coronaviruses. Significantly, compound 2 dis...

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Detalles Bibliográficos
Autores principales: Peters, Hannah L., Jochmans, Dirk, de Wilde, Adriaan H., Posthuma, Clara C., Snijder, Eric J., Neyts, Johan, Seley-Radtke, Katherine L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466200/
https://www.ncbi.nlm.nih.gov/pubmed/26048809
http://dx.doi.org/10.1016/j.bmcl.2015.05.039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466200/
https://www.ncbi.nlm.nih.gov/pubmed/26048809
http://dx.doi.org/10.1016/j.bmcl.2015.05.039

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