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Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity
A series of doubly flexible nucleoside analogues were designed based on the acyclic sugar scaffold of acyclovir and the flex-base moiety found in the fleximers. The target compounds were evaluated for their antiviral potential and found to inhibit several coronaviruses. Significantly, compound 2 dis...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Ltd.
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466200/ https://www.ncbi.nlm.nih.gov/pubmed/26048809 http://dx.doi.org/10.1016/j.bmcl.2015.05.039 |