Extended ubiquitin species are protein-based DUB inhibitors

A frame-shift mutation in the transcript of the ubiquitin-B gene leads to a C-terminally extended ubiquitin, UBB(+1). UBB(+1) has been considered to inhibit proteasomes, and as such to be the underlying cause for toxic protein buildup correlated with certain neuropathological conditions. We demonstr...

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Detalles Bibliográficos
Autores principales: Krutauz, Daria, Reis, Noa, Nakasone, Mark A., Siman, Peter, Zhang, Daoning, Kirkpatrick, Donald S., Gygi, Steven P., Brik, Ashraf, Fushman, David, Glickman, Michael H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466224/
https://www.ncbi.nlm.nih.gov/pubmed/24997605
http://dx.doi.org/10.1038/nchembio.1574

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466224/
https://www.ncbi.nlm.nih.gov/pubmed/24997605
http://dx.doi.org/10.1038/nchembio.1574

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