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Structure-Based Peptide Design to Modulate Amyloid Beta Aggregation and Reduce Cytotoxicity
The deposition of Aβ peptide in the brain is the key event in Alzheimer disease progression. Therefore, the prevention of Aβ self assembly into disease-associated oligomers is a logical strategy for treatment. π stacking is known to provide structural stability to many amyloids; two phenylalanine re...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466325/ https://www.ncbi.nlm.nih.gov/pubmed/26070139 http://dx.doi.org/10.1371/journal.pone.0129087 |