Oral Calcidiol Is More Effective Than Cholecalciferol Supplementation to Reach Adequate 25(OH)D Levels in Patients with Autoimmune Diseases Chronically Treated with Low Doses of Glucocorticoids: A “Real-Life” Study

Glucocorticoids (GCs) are the cornerstone of the therapy in many autoimmune and inflammatory diseases. However, it is well known that their use is a double edged sword, as their beneficial effects are associated almost universally with unwanted effects, as, for example glucocorticoid-induced osteopo...

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Autores principales: Ortego-Jurado, Miguel, Callejas-Rubio, José-Luis, Ríos-Fernández, Raquel, González-Moreno, Juan, González Ramírez, Amanda Rocío, González-Gay, Miguel A., Ortego-Centeno, Norberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466436/
https://www.ncbi.nlm.nih.gov/pubmed/26124976
http://dx.doi.org/10.1155/2015/729451
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author Ortego-Jurado, Miguel
Callejas-Rubio, José-Luis
Ríos-Fernández, Raquel
González-Moreno, Juan
González Ramírez, Amanda Rocío
González-Gay, Miguel A.
Ortego-Centeno, Norberto
author_facet Ortego-Jurado, Miguel
Callejas-Rubio, José-Luis
Ríos-Fernández, Raquel
González-Moreno, Juan
González Ramírez, Amanda Rocío
González-Gay, Miguel A.
Ortego-Centeno, Norberto
author_sort Ortego-Jurado, Miguel
collection PubMed
description Glucocorticoids (GCs) are the cornerstone of the therapy in many autoimmune and inflammatory diseases. However, it is well known that their use is a double edged sword, as their beneficial effects are associated almost universally with unwanted effects, as, for example glucocorticoid-induced osteoporosis (GIO). Over the last years, several clinical practice guidelines emphasize the need of preventing bone mass loss and reduce the incidence of fractures associated with GC use. Calcium and vitamin D supplementation, as adjunctive therapy, are included in all the practice guidelines. However, no standard vitamin D dose has been established. Several studies with postmenopausal women show that maintaining the levels above 30–33 ng/mL help improve the response to bisphosphonates. It is unknown if the response is the same in GIO, but in the clinical practice the levels are maintained at around the same values. In this study we demonstrate that patients with autoimmune diseases, undergoing glucocorticoid therapy, often present suboptimal 25(OH)D levels. Patients with higher body mass index and those receiving higher doses of glucocorticoids are at increased risk of having lower levels of 25(OH)D. In these patients, calcidiol supplementations are more effective than cholecalciferol to reach adequate 25(OH)D levels.
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spelling pubmed-44664362015-06-29 Oral Calcidiol Is More Effective Than Cholecalciferol Supplementation to Reach Adequate 25(OH)D Levels in Patients with Autoimmune Diseases Chronically Treated with Low Doses of Glucocorticoids: A “Real-Life” Study Ortego-Jurado, Miguel Callejas-Rubio, José-Luis Ríos-Fernández, Raquel González-Moreno, Juan González Ramírez, Amanda Rocío González-Gay, Miguel A. Ortego-Centeno, Norberto J Osteoporos Research Article Glucocorticoids (GCs) are the cornerstone of the therapy in many autoimmune and inflammatory diseases. However, it is well known that their use is a double edged sword, as their beneficial effects are associated almost universally with unwanted effects, as, for example glucocorticoid-induced osteoporosis (GIO). Over the last years, several clinical practice guidelines emphasize the need of preventing bone mass loss and reduce the incidence of fractures associated with GC use. Calcium and vitamin D supplementation, as adjunctive therapy, are included in all the practice guidelines. However, no standard vitamin D dose has been established. Several studies with postmenopausal women show that maintaining the levels above 30–33 ng/mL help improve the response to bisphosphonates. It is unknown if the response is the same in GIO, but in the clinical practice the levels are maintained at around the same values. In this study we demonstrate that patients with autoimmune diseases, undergoing glucocorticoid therapy, often present suboptimal 25(OH)D levels. Patients with higher body mass index and those receiving higher doses of glucocorticoids are at increased risk of having lower levels of 25(OH)D. In these patients, calcidiol supplementations are more effective than cholecalciferol to reach adequate 25(OH)D levels. Hindawi Publishing Corporation 2015 2015-06-01 /pmc/articles/PMC4466436/ /pubmed/26124976 http://dx.doi.org/10.1155/2015/729451 Text en Copyright © 2015 Miguel Ortego-Jurado et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ortego-Jurado, Miguel
Callejas-Rubio, José-Luis
Ríos-Fernández, Raquel
González-Moreno, Juan
González Ramírez, Amanda Rocío
González-Gay, Miguel A.
Ortego-Centeno, Norberto
Oral Calcidiol Is More Effective Than Cholecalciferol Supplementation to Reach Adequate 25(OH)D Levels in Patients with Autoimmune Diseases Chronically Treated with Low Doses of Glucocorticoids: A “Real-Life” Study
title Oral Calcidiol Is More Effective Than Cholecalciferol Supplementation to Reach Adequate 25(OH)D Levels in Patients with Autoimmune Diseases Chronically Treated with Low Doses of Glucocorticoids: A “Real-Life” Study
title_full Oral Calcidiol Is More Effective Than Cholecalciferol Supplementation to Reach Adequate 25(OH)D Levels in Patients with Autoimmune Diseases Chronically Treated with Low Doses of Glucocorticoids: A “Real-Life” Study
title_fullStr Oral Calcidiol Is More Effective Than Cholecalciferol Supplementation to Reach Adequate 25(OH)D Levels in Patients with Autoimmune Diseases Chronically Treated with Low Doses of Glucocorticoids: A “Real-Life” Study
title_full_unstemmed Oral Calcidiol Is More Effective Than Cholecalciferol Supplementation to Reach Adequate 25(OH)D Levels in Patients with Autoimmune Diseases Chronically Treated with Low Doses of Glucocorticoids: A “Real-Life” Study
title_short Oral Calcidiol Is More Effective Than Cholecalciferol Supplementation to Reach Adequate 25(OH)D Levels in Patients with Autoimmune Diseases Chronically Treated with Low Doses of Glucocorticoids: A “Real-Life” Study
title_sort oral calcidiol is more effective than cholecalciferol supplementation to reach adequate 25(oh)d levels in patients with autoimmune diseases chronically treated with low doses of glucocorticoids: a “real-life” study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466436/
https://www.ncbi.nlm.nih.gov/pubmed/26124976
http://dx.doi.org/10.1155/2015/729451
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