Design, Synthesis and Structure-Activity Relationship Studies of Novel Survivin Inhibitors with Potent Anti-Proliferative Properties

The anti-apoptotic protein survivin is highly expressed in most human cancer cells, but has very low expression in normal differentiated cells. Thus survivin is considered as an attractive cancer drug target. Herein we report the design and synthesis of a series of novel survivin inhibitors based on...

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Detalles Bibliográficos
Autores principales: Xiao, Min, Wang, Jin, Lin, Zongtao, Lu, Yan, Li, Zhenmei, White, Stephen W., Miller, Duane D., Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466525/
https://www.ncbi.nlm.nih.gov/pubmed/26070194
http://dx.doi.org/10.1371/journal.pone.0129807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466525/
https://www.ncbi.nlm.nih.gov/pubmed/26070194
http://dx.doi.org/10.1371/journal.pone.0129807

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