Depletion of eIF2.GTP.Met-tRNA(i) translation initiation complex up-regulates BRCA1 expression in vitro and in vivo

Most sporadic breast and ovarian cancers express low levels of the breast cancer susceptibility gene, BRCA1. The BRCA1 gene produces two transcripts, mRNAa and mRNAb. mRNAb, present in breast cancer but not in normal mammary epithelial cells, contains three upstream open reading frames (uORFs) in it...

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Detalles Bibliográficos
Autores principales: Aktas, Bertal H., Bordelois, Paula, Peker, Selen, Merajver, Sophia, Halperin, Jose A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466658/
https://www.ncbi.nlm.nih.gov/pubmed/25762631

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466658/
https://www.ncbi.nlm.nih.gov/pubmed/25762631

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