Self-association of Trimethylguanosine Synthase Tgs1 is required for efficient snRNA/snoRNA trimethylation and pre-rRNA processing

Trimethylguanosine Synthase catalyses transfer of two methyl groups to the m(7)G cap of RNA polymerase II transcribed snRNAs, snoRNAs, and telomerase RNA TLC1 to form a 2,2,7-trimethylguanosine cap. While in vitro studies indicate that Tgs1 functions as a monomer and the dimethylation of m(7)G caps...

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Detalles Bibliográficos
Autores principales: Boon, Kum-Loong, Pearson, Michael David, Koš, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466884/
https://www.ncbi.nlm.nih.gov/pubmed/26074133
http://dx.doi.org/10.1038/srep11282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466884/
https://www.ncbi.nlm.nih.gov/pubmed/26074133
http://dx.doi.org/10.1038/srep11282

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