Acquisition of resistance to trastuzumab in gastric cancer cells is associated with activation of IL-6/STAT3/Jagged-1/Notch positive feedback loop

In the present study, we demonstrate that prolonged treatment by trastuzumab induced resistance of NCI-N87 gastric cancer cells to trastuzumab. The resistant cells possessed typical characteristics of epithelial to mesenchymal transition (EMT)/cancer stem cells and acquired more invasive and metasta...

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Detalles Bibliográficos
Autores principales: Yang, Zhengyan, Guo, Liang, Liu, Dan, Sun, Limin, Chen, Hongyu, Deng, Que, Liu, Yanjun, Yu, Ming, Ma, Yuanfang, Guo, Ning, Shi, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467134/
https://www.ncbi.nlm.nih.gov/pubmed/25669984

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467134/
https://www.ncbi.nlm.nih.gov/pubmed/25669984

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