Inhibition of DNA methyltransferase as a novel therapeutic strategy to overcome acquired resistance to dual PI3K/mTOR inhibitors

Dual PI3K/mTOR(phosphatidylinositol 3-kinase/mammalian target of rapamycin) inhibitors are being evaluated clinically for the treatment of tumors with a hyperactivated PI3K/mTOR pathway. However, unexpected outcomes were obtained in clinical studies of cancer patients with an aberrant PI3K pathway....

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Detalles Bibliográficos
Autores principales: Qian, Xiao-jun, Li, Yun-tian, Yu, Yan, Yang, Fen, Deng, Rong, Ji, Jiao, Jiao, Lin, Li, Xuan, Wu, Rui-Yan, Chen, Wen-Dan, Feng, Gong-Kan, Zhu, Xiao-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467138/
https://www.ncbi.nlm.nih.gov/pubmed/25762617

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467138/
https://www.ncbi.nlm.nih.gov/pubmed/25762617

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