Intravenous Pharmacokinetics, Local Tolerability, and Hemolysis of an SBE7-β-Cyclodextrin Formulation of the Neurokinin-1 Receptor Antagonist Vestipitant

Vestipitant is a potent and selective neurokinin 1 (NK-1) receptor antagonist that was investigated as a potential treatment for post-operative nausea and vomiting (PONV). A previous mannitol-based formulation of vestipitant was associated with hemolytic activity in preclinical studies. In an effort...

Descripción completa

Detalles Bibliográficos
Autores principales: Brigandi, Richard A, Russ, Steven F, Petit, Chantal, Johnson, Brendan, Croy, Scott, Hodsman, Peter, Muller, Fran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467239/
https://www.ncbi.nlm.nih.gov/pubmed/26097793
http://dx.doi.org/10.1002/cpdd.128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467239/
https://www.ncbi.nlm.nih.gov/pubmed/26097793
http://dx.doi.org/10.1002/cpdd.128

Ejemplares similares