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Intravenous Pharmacokinetics, Local Tolerability, and Hemolysis of an SBE7-β-Cyclodextrin Formulation of the Neurokinin-1 Receptor Antagonist Vestipitant

Vestipitant is a potent and selective neurokinin 1 (NK-1) receptor antagonist that was investigated as a potential treatment for post-operative nausea and vomiting (PONV). A previous mannitol-based formulation of vestipitant was associated with hemolytic activity in preclinical studies. In an effort...

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Detalles Bibliográficos
Autores principales:	Brigandi, Richard A, Russ, Steven F, Petit, Chantal, Johnson, Brendan, Croy, Scott, Hodsman, Peter, Muller, Fran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467239/ https://www.ncbi.nlm.nih.gov/pubmed/26097793 http://dx.doi.org/10.1002/cpdd.128

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