The Effect of Food and Formulation on the Pharmacokinetics, Safety, and Tolerability of GSK1322322 in Healthy Volunteers

GSK1322322 is the first in a new class of antibiotics that inhibit peptide deformylase, necessary for bacterial protein maturation. Previously, low absolute bioavailability was observed for the 1500-mg oral tablet formulation, resulting in a less than dose-proportional increase from the 1000-mg dose...

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Detalles Bibliográficos
Autores principales: Naderer, Odin, Jones, Lori S, Zhu, John, Coffin, Mark D, Kurtinecz, Milena, Dumont, Etienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467258/
https://www.ncbi.nlm.nih.gov/pubmed/26097792
http://dx.doi.org/10.1002/cpdd.165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467258/
https://www.ncbi.nlm.nih.gov/pubmed/26097792
http://dx.doi.org/10.1002/cpdd.165

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