Dihydroartemisinin and its derivative induce apoptosis in acute myeloid leukemia through Noxa-mediated pathway requiring iron and endoperoxide moiety

Anti-apoptotic protein Mcl-1 plays an important role in protecting cell from death in acute myeloid leukemia (AML). The apoptosis blocking activity of Mcl-1 is inhibited by BH3-only protein Noxa. We found that dihydroartemisinin (DHA) and its derivative X-11 are potent apoptosis inducers in AML cell...

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Detalles Bibliográficos
Autores principales: Zhao, Xuan, Zhong, Hang, Wang, Rui, Liu, Dan, Waxman, Samuel, Zhao, Linxiang, Jing, Yongkui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467388/
https://www.ncbi.nlm.nih.gov/pubmed/25714024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467388/
https://www.ncbi.nlm.nih.gov/pubmed/25714024

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