Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel

Persistent phosphorylation of signal transducers and activators of transcription 3 (STAT3) is frequently observed in tumor cells. We found that brassinin (BSN) suppressed both constitutive and IL-6-inducible STAT3 activation in lung cancer cells. Moreover, BSN induced PIAS-3 protein and mRNA, wherea...

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Detalles Bibliográficos
Autores principales: Lee, Jong Hyun, Kim, Chulwon, Sethi, Gautam, Ahn, Kwang Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467444/
https://www.ncbi.nlm.nih.gov/pubmed/25788267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467444/
https://www.ncbi.nlm.nih.gov/pubmed/25788267

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