Regulation of Nucleotide Metabolism by Mutant p53 Contributes to its Gain-of-Function Activities

Mutant p53 (mtp53) is an oncogene that drives cancer cell proliferation. Here we report that mtp53 associates with the promoters of numerous nucleotide metabolism genes (NMG). Mtp53 knockdown reduces NMG expression and substantially depletes nucleotide pools, which attenuates GTP dependent protein (...

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Detalles Bibliográficos
Autores principales: Kollareddy, Madhusudhan, Dimitrova, Elizabeth, Vallabhaneni, Krishna C., Chan, Adriano, Le, Thuc, Chauhan, Krishna M., Carrero, Zunamys I., Ramakrishnan, Gopalakrishnan, Watabe, Kounosuke, Haupt, Ygal, Haupt, Sue, Pochampally, Radhika, Boss, Gerard R., Romero, Damian G., Radu, Caius G., Martinez, Luis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467467/
https://www.ncbi.nlm.nih.gov/pubmed/26067754
http://dx.doi.org/10.1038/ncomms8389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467467/
https://www.ncbi.nlm.nih.gov/pubmed/26067754
http://dx.doi.org/10.1038/ncomms8389

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