Patterns of HER2 Gene Amplification and Response to Anti-HER2 Therapies

A chromosomal region that includes the gene encoding HER2, a receptor tyrosine kinase (RTK), is amplified in 20% of breast cancers. Although these tumors tend to respond to drugs directed against HER2, they frequently become resistant and resume their malignant progression. Gene amplification in dou...

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Detalles Bibliográficos
Autores principales: Vicario, Rocio, Peg, Vicente, Morancho, Beatriz, Zacarias-Fluck, Mariano, Zhang, Junjie, Martínez-Barriocanal, Águeda, Navarro Jiménez, Alexandra, Aura, Claudia, Burgues, Octavio, Lluch, Ana, Cortés, Javier, Nuciforo, Paolo, Rubio, Isabel T., Marangoni, Elisabetta, Deeds, James, Boehm, Markus, Schlegel, Robert, Tabernero, Josep, Mosher, Rebecca, Arribas, Joaquín
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467984/
https://www.ncbi.nlm.nih.gov/pubmed/26075403
http://dx.doi.org/10.1371/journal.pone.0129876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467984/
https://www.ncbi.nlm.nih.gov/pubmed/26075403
http://dx.doi.org/10.1371/journal.pone.0129876

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