Palmitate Inhibits SIRT1-Dependent BMAL1/CLOCK Interaction and Disrupts Circadian Gene Oscillations in Hepatocytes

Elevated levels of serum saturated fatty acid palmitate have been shown to promote insulin resistance, increase cellular ROS production, and trigger cell apoptosis in hepatocytes during the development of obesity. However, it remains unclear whether palmitate directly impacts the circadian clock in...

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Detalles Bibliográficos
Autores principales: Tong, Xin, Zhang, Deqiang, Arthurs, Blake, Li, Pei, Durudogan, Leigh, Gupta, Neil, Yin, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468094/
https://www.ncbi.nlm.nih.gov/pubmed/26075729
http://dx.doi.org/10.1371/journal.pone.0130047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468094/
https://www.ncbi.nlm.nih.gov/pubmed/26075729
http://dx.doi.org/10.1371/journal.pone.0130047

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