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Computational Design of the β-Sheet Surface of a Red Fluorescent Protein Allows Control of Protein Oligomerization
Computational design has been used with mixed success for the design of protein surfaces, with directed evolution heretofore providing better practical solutions than explicit design. Directed evolution, however, requires a tractable high-throughput screen because the random nature of mutation does...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468108/ https://www.ncbi.nlm.nih.gov/pubmed/26075618 http://dx.doi.org/10.1371/journal.pone.0130582 |