A 20 bp Duplication in Exon 2 of the Aristaless-Like Homeobox 4 Gene (ALX4) Is the Candidate Causative Mutation for Tibial Hemimelia Syndrome in Galloway Cattle

Aristaless-like homeobox 4 (ALX4) gene is an important transcription regulator in skull and limb development. In humans and mice ALX4 mutations or loss of function result in a number of skeletal and organ malformations, including polydactyly, tibial hemimelia, omphalocele, biparietal foramina, impai...

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Detalles Bibliográficos
Autores principales: Brenig, Bertram, Schütz, Ekkehard, Hardt, Michael, Scheuermann, Petra, Freick, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468193/
https://www.ncbi.nlm.nih.gov/pubmed/26076463
http://dx.doi.org/10.1371/journal.pone.0129208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468193/
https://www.ncbi.nlm.nih.gov/pubmed/26076463
http://dx.doi.org/10.1371/journal.pone.0129208

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