Therapeutic Efficacy of a Subunit Vaccine in Controlling Chronic Trypanosoma cruzi Infection and Chagas Disease Is Enhanced by Glutathione Peroxidase Over-Expression

Trypanosoma cruzi-induced oxidative and inflammatory responses are implicated in chagasic cardiomyopathy. In this study, we examined the therapeutic utility of a subunit vaccine against T. cruzi and determined if glutathione peroxidase (GPx1, antioxidant) protects the heart from chagasic pathogenesi...

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Detalles Bibliográficos
Autores principales: Gupta, Shivali, Smith, Charity, Auclair, Sarah, Delgadillo, Anahi De Jesus, Garg, Nisha Jain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468200/
https://www.ncbi.nlm.nih.gov/pubmed/26075398
http://dx.doi.org/10.1371/journal.pone.0130562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468200/
https://www.ncbi.nlm.nih.gov/pubmed/26075398
http://dx.doi.org/10.1371/journal.pone.0130562

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