FS-93, an Hsp90 inhibitor, induces G2/M arrest and apoptosis via the degradation of client proteins in oncogene addicted and derived resistant cancer cells

Inhibition of heat shock protein 90 (Hsp90) abrogates signaling of multiple aberrantly activated oncogenic proteins simultaneously, particularly mutated or amplified kinases, which provides an attractive approach for cancer treatment. Here, we described that FS-93, a potent Hsp90 inhibitor, impacted...

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Detalles Bibliográficos
Autores principales: Zhang, Liping, Shen, Aijun, Wang, Lu, Liu, Hongchun, Chen, Danqi, Xiong, Bing, Shen, Jingkang, Geng, Meiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468327/
https://www.ncbi.nlm.nih.gov/pubmed/26097875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468327/
https://www.ncbi.nlm.nih.gov/pubmed/26097875

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