Methylation changes in the TFAP2E promoter region are associated with BRAF mutation and poorer overall & disease free survival in colorectal cancer

INTRODUCTION: BRAF mutant colorectal cancer carries a poor prognosis which is thought to be related to poor response to conventional chemotherapy. BRAF mutation is associated with the serrated tumour phenotype. We hypothesised that one of the mechanisms by which BRAF mutant colorectal cancer demonst...

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Detalles Bibliográficos
Autores principales: Beggs, Andrew D., Dilworth, Mark P., Domingo, Enric, Midgley, Rachel, Kerr, David, Tomlinson, Ian P.M., Middleton, Gary W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468337/
https://www.ncbi.nlm.nih.gov/pubmed/26097884

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468337/
https://www.ncbi.nlm.nih.gov/pubmed/26097884

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