An AXIN2 Mutant Allele Associated With Predisposition to Colorectal Neoplasia Has Context-Dependent Effects on AXIN2 Protein Function()

Heterozygous, germline nonsense mutations in AXIN2 have been reported in two families with oligodontia and colorectal cancer (CRC) predisposition, including an AXIN2 1989G>A mutation. Somatic AXIN2 mutations predicted to generate truncated AXIN2 (trAXIN2) proteins have been reported in some CRCs....

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Detalles Bibliográficos
Autores principales: Mazzoni, Serina M., Petty, Elizabeth M., Stoffel, Elena M., Fearon, Eric R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468370/
https://www.ncbi.nlm.nih.gov/pubmed/26025668
http://dx.doi.org/10.1016/j.neo.2015.04.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468370/
https://www.ncbi.nlm.nih.gov/pubmed/26025668
http://dx.doi.org/10.1016/j.neo.2015.04.006

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