Antisense RNA foci in the motor neurons of C9ORF72-ALS patients are associated with TDP-43 proteinopathy

GGGGCC repeat expansions of C9ORF72 represent the most common genetic variant of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. We and others have proposed that RNA transcribed from the repeat sequence is toxic via sequestration of RNA-binding factors. Both GGGGCC-repeat (sense) an...

Descripción completa

Detalles Bibliográficos
Autores principales: Cooper-Knock, Johnathan, Higginbottom, Adrian, Stopford, Matthew J., Highley, J. Robin, Ince, Paul G., Wharton, Stephen B., Pickering-Brown, Stuart, Kirby, Janine, Hautbergue, Guillaume M., Shaw, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468790/
https://www.ncbi.nlm.nih.gov/pubmed/25943887
http://dx.doi.org/10.1007/s00401-015-1429-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468790/
https://www.ncbi.nlm.nih.gov/pubmed/25943887
http://dx.doi.org/10.1007/s00401-015-1429-9

Ejemplares similares