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Can Selective MHC Downregulation Explain the Specificity and Genetic Diversity of NK Cell Receptors?
Natural killer (NK) cells express inhibiting receptors (iNKRs), which specifically bind MHC-I molecules on the surface of healthy cells. When the expression of MHC-I on the cell surface decreases, which might occur during certain viral infections and cancer, iNKRs lose inhibiting signals and the inf...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468891/ https://www.ncbi.nlm.nih.gov/pubmed/26136746 http://dx.doi.org/10.3389/fimmu.2015.00311 |