Pharmacogenomic and clinical data link non-pharmacokinetic metabolic dysregulation to drug side effect pathogenesis

Drug side effects cause a significant clinical and economic burden. However, mechanisms of drug action underlying side effect pathogenesis remain largely unknown. Here, we integrate pharmacogenomic and clinical data with a human metabolic network and find that non-pharmacokinetic metabolic pathways...

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Detalles Bibliográficos
Autores principales: Zielinski, Daniel C., Filipp, Fabian V., Bordbar, Aarash, Jensen, Kasper, Smith, Jeffrey W., Herrgard, Markus J., Mo, Monica L., Palsson, Bernhard O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468904/
https://www.ncbi.nlm.nih.gov/pubmed/26055627
http://dx.doi.org/10.1038/ncomms8101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468904/
https://www.ncbi.nlm.nih.gov/pubmed/26055627
http://dx.doi.org/10.1038/ncomms8101

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