The Relationship between Zinc Status and Inflammatory Marker Levels in Rural Korean Adults Aged 40 and Older

BACKGROUND: Serum cytokines and C-reactive protein (CRP) are known as one of the major risk factors in atherosclerosis. The antioxidant and anti-inflammatory properties of zinc have been suggested, but few data are available on the relationship between zinc status and inflammatory markers in epidemi...

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Autores principales: Jung, Sukyoung, Kim, Mi Kyung, Choi, Bo Youl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469681/
https://www.ncbi.nlm.nih.gov/pubmed/26080030
http://dx.doi.org/10.1371/journal.pone.0130016
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author Jung, Sukyoung
Kim, Mi Kyung
Choi, Bo Youl
author_facet Jung, Sukyoung
Kim, Mi Kyung
Choi, Bo Youl
author_sort Jung, Sukyoung
collection PubMed
description BACKGROUND: Serum cytokines and C-reactive protein (CRP) are known as one of the major risk factors in atherosclerosis. The antioxidant and anti-inflammatory properties of zinc have been suggested, but few data are available on the relationship between zinc status and inflammatory markers in epidemiological studies. OBJECTIVE: The present study aims to investigate the cross-sectional relationships of serum cytokines and CRP with dietary zinc intake and serum zinc levels in healthy men and women aged 40 and older in rural areas of South Korea. MATERIALS AND METHODS: A group of 1,055 subjects (404 men, 651 women) was included in dietary zinc analysis while another group of 695 subjects (263 men, 432 women) was included in serum zinc analysis. Serum IL-6, TNF-α, and CRP were measured as inflammatory markers. RESULTS: There was no significant inverse relationship between dietary zinc intake and inflammatory markers. We found a significant inverse relationship between serum zinc levels and all three inflammatory markers in women (P for trend = 0.0236 for IL-6; P for trend = 0.0017 for TNF-α; P for trend = 0.0301 for CRP) and between serum zinc levels and a single inflammatory marker (IL-6) in men (P for trend = 0.0191), although all R2 values by regression were less than 10%. CONCLUSION: In conclusion, serum zinc levels may be inversely related to inflammatory markers (IL-6, TNF-α, and CRP), particularly in women.
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spelling pubmed-44696812015-06-22 The Relationship between Zinc Status and Inflammatory Marker Levels in Rural Korean Adults Aged 40 and Older Jung, Sukyoung Kim, Mi Kyung Choi, Bo Youl PLoS One Research Article BACKGROUND: Serum cytokines and C-reactive protein (CRP) are known as one of the major risk factors in atherosclerosis. The antioxidant and anti-inflammatory properties of zinc have been suggested, but few data are available on the relationship between zinc status and inflammatory markers in epidemiological studies. OBJECTIVE: The present study aims to investigate the cross-sectional relationships of serum cytokines and CRP with dietary zinc intake and serum zinc levels in healthy men and women aged 40 and older in rural areas of South Korea. MATERIALS AND METHODS: A group of 1,055 subjects (404 men, 651 women) was included in dietary zinc analysis while another group of 695 subjects (263 men, 432 women) was included in serum zinc analysis. Serum IL-6, TNF-α, and CRP were measured as inflammatory markers. RESULTS: There was no significant inverse relationship between dietary zinc intake and inflammatory markers. We found a significant inverse relationship between serum zinc levels and all three inflammatory markers in women (P for trend = 0.0236 for IL-6; P for trend = 0.0017 for TNF-α; P for trend = 0.0301 for CRP) and between serum zinc levels and a single inflammatory marker (IL-6) in men (P for trend = 0.0191), although all R2 values by regression were less than 10%. CONCLUSION: In conclusion, serum zinc levels may be inversely related to inflammatory markers (IL-6, TNF-α, and CRP), particularly in women. Public Library of Science 2015-06-16 /pmc/articles/PMC4469681/ /pubmed/26080030 http://dx.doi.org/10.1371/journal.pone.0130016 Text en © 2015 Jung et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Jung, Sukyoung
Kim, Mi Kyung
Choi, Bo Youl
The Relationship between Zinc Status and Inflammatory Marker Levels in Rural Korean Adults Aged 40 and Older
title The Relationship between Zinc Status and Inflammatory Marker Levels in Rural Korean Adults Aged 40 and Older
title_full The Relationship between Zinc Status and Inflammatory Marker Levels in Rural Korean Adults Aged 40 and Older
title_fullStr The Relationship between Zinc Status and Inflammatory Marker Levels in Rural Korean Adults Aged 40 and Older
title_full_unstemmed The Relationship between Zinc Status and Inflammatory Marker Levels in Rural Korean Adults Aged 40 and Older
title_short The Relationship between Zinc Status and Inflammatory Marker Levels in Rural Korean Adults Aged 40 and Older
title_sort relationship between zinc status and inflammatory marker levels in rural korean adults aged 40 and older
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469681/
https://www.ncbi.nlm.nih.gov/pubmed/26080030
http://dx.doi.org/10.1371/journal.pone.0130016
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