Dimeric Organization of Blood Coagulation Factor VIII bound to Lipid Nanotubes

Membrane-bound Factor VIII (FVIII) has a critical function in blood coagulation as the pro-cofactor to the serine-protease Factor IXa (FIXa) in the FVIIIa-FIXa complex assembled on the activated platelet membrane. Defects or deficiency of FVIII cause Hemophilia A, a mild to severe bleeding disorder....

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Detalles Bibliográficos
Autores principales: Dalm, Daniela, Galaz-Montoya, Jesus G., Miller, Jaimy L., Grushin, Kirill, Villalobos, Alex, Koyfman, Alexey Y., Schmid, Michael F., Stoilova-McPhie, Svetla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469981/
https://www.ncbi.nlm.nih.gov/pubmed/26082135
http://dx.doi.org/10.1038/srep11212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469981/
https://www.ncbi.nlm.nih.gov/pubmed/26082135
http://dx.doi.org/10.1038/srep11212

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