Cargando…

The androgen receptor confers protection against diet-induced atherosclerosis, obesity, and dyslipidemia in female mice

Androgens have important cardiometabolic actions in males, but their metabolic role in females is unclear. To determine the physiologic androgen receptor (AR)–dependent actions of androgens on atherogenesis in female mice, we generated female AR-knockout (ARKO) mice on an atherosclerosis-prone apoli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fagman, Johan B., Wilhelmson, Anna S., Motta, Benedetta M., Pirazzi, Carlo, Alexanderson, Camilla, De Gendt, Karel, Verhoeven, Guido, Holmäng, Agneta, Anesten, Fredrik, Jansson, John-Olov, Levin, Malin, Borén, Jan, Ohlsson, Claes, Krettek, Alexandra, Romeo, Stefano, Tivesten, Åsa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Federation of American Societies for Experimental Biology 2015
Materias:	Research Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470404/ https://www.ncbi.nlm.nih.gov/pubmed/25550469 http://dx.doi.org/10.1096/fj.14-259234

Ejemplares similares

The Bone Sparing Effects of 2-Methoxyestradiol Are Mediated via Estrogen Receptor-α in Male Mice
por: Eriksson, Anna L., et al.
Publicado: (2016)

Androgen Receptors in Epithelial Cells Regulate Thymopoiesis and Recent Thymic Emigrants in Male Mice
por: Wilhelmson, Anna S., et al.
Publicado: (2020)

Increased diet-induced fatty streak formation in female mice with deficiency of liver-derived insulin-like growth factor-I
por: Svensson, Johan, et al.
Publicado: (2015)

Deficiency of mature B cells does not alter the atherogenic response to castration in male mice
por: Wilhelmson, Anna S., et al.
Publicado: (2022)

PCSK9 Inhibitors in a Statin-Intolerant Transgender Man With Heterozygous Familial Hypercholesterolemia: A Case Report
por: Pirazzi, Carlo, et al.
Publicado: (2019)

The dual hypothesis of homeostatic body weight regulation, including gravity-dependent and leptin-dependent actions
por: Jansson, John-Olov, et al.
Publicado: (2023)

A Body Weight Sensor Regulates Prepubertal Growth via the Somatotropic Axis in Male Rats
por: Jansson, John-Olov, et al.
Publicado: (2021)

Testosterone Protects Against Atherosclerosis in Male Mice by Targeting Thymic Epithelial Cells—Brief Report
por: Wilhelmson, Anna S., et al.
Publicado: (2018)

Androgens and spermatogenesis: lessons from transgenic mouse models
por: Verhoeven, Guido, et al.
Publicado: (2010)

The gravitostat theory: More data needed
por: Ohlsson, Claes, et al.
Publicado: (2020)

Occurrence of testicular microlithiasis in androgen insensitive hypogonadal mice
por: O'Shaughnessy, Peter J, et al.
Publicado: (2009)

Cardiometabolic Risk Factors and Endogenous Sex Hormones in Postmenopausal Women: A Cross-Sectional Study
por: Ottarsdottir, Kristin, et al.
Publicado: (2022)

Targeted Inactivation of the Androgen Receptor Gene in Murine Proximal Epididymis Causes Epithelial Hypotrophy and Obstructive Azoospermia
por: Krutskikh, Anton, et al.
Publicado: (2011)

Dihydrotestosterone levels at birth associate positively with higher proportions of circulating immature/naïve CD5(+) B cells in boys
por: Lundell, Anna-Carin, et al.
Publicado: (2017)

Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors
por: O'Shaughnessy, P J, et al.
Publicado: (2010)

Revisiting the critical weight hypothesis for regulation of pubertal timing in boys
por: Bygdell, Maria, et al.
Publicado: (2020)

Low Progesterone and Low Estradiol Levels Associate With Abdominal Aortic Aneurysms in Men
por: Ohlsson, Claes, et al.
Publicado: (2021)

Free lipid and computerized determination of adipocyte size
por: Svensson, Henrik, et al.
Publicado: (2018)

Fibroblast growth factor 23, mineral metabolism and mortality among elderly men (Swedish MrOs)
por: Westerberg, Per-Anton, et al.
Publicado: (2013)

Estren promotes androgen phenotypes in primary lymphoid organs and submandibular glands
por: Islander, Ulrika, et al.
Publicado: (2005)

Monitoring of Lipids, Enzymes, and Creatine Kinase in Patients on Lipid-Lowering Drug Therapy
por: Wiklund, Olov, et al.
Publicado: (2013)

Serum DHEA and Testosterone Levels Associate Inversely With Coronary Artery Calcification in Elderly Men
por: Ohlsson, Claes, et al.
Publicado: (2023)

Increased weight loading reduces body weight and body fat in obese subjects – A proof of concept randomized clinical trial
por: Ohlsson, Claes, et al.
Publicado: (2020)

The association between Single Nucleotide Polymorphisms of Klotho Gene and Mortality in Elderly Men: The MrOS Sweden Study
por: Wu, Ping-Hsun, et al.
Publicado: (2020)

Selective Ablation of the Androgen Receptor in Mouse Sertoli Cells Affects Sertoli Cell Maturation, Barrier Formation and Cytoskeletal Development
por: Willems, Ariane, et al.
Publicado: (2010)

Adipose tissue and body composition in women six years after gestational diabetes: factors associated with development of type 2 diabetes
por: Svensson, Henrik, et al.
Publicado: (2018)

Liver-Derived IGF-I Regulates Mean Life Span in Mice
por: Svensson, Johan, et al.
Publicado: (2011)

Body weight homeostat that regulates fat mass independently of leptin in rats and mice
por: Jansson, John-Olov, et al.
Publicado: (2018)

PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells
por: Pirazzi, Carlo, et al.
Publicado: (2014)

Interleukin‐6 in the central amygdala is bioactive and co‐localised with glucagon‐like peptide‐1 receptor
por: Anesten, Fredrik, et al.
Publicado: (2019)

Estrogen and androgen-converting enzymes 17β-hydroxysteroid dehydrogenase and their involvement in cancer: with a special focus on 17β-hydroxysteroid dehydrogenase type 1, 2, and breast cancer
por: Hilborn, Erik, et al.
Publicado: (2017)

Androgen receptor expression predicts beneficial tamoxifen response in oestrogen receptor-α-negative breast cancer
por: Hilborn, Erik, et al.
Publicado: (2016)

Rats with steroid-induced polycystic ovaries develop hypertension and increased sympathetic nervous system activity
por: Stener-Victorin, Elisabet, et al.
Publicado: (2005)

Genetic diagnosis of familial hypercholesterolaemia by targeted next-generation sequencing
por: Maglio, C, et al.
Publicado: (2014)

Cardiometabolic Risk Factors in Rosuvastatin-Treated Men with Mixed Dyslipidemia and Early-Onset Androgenic Alopecia
por: Krysiak, Robert, et al.
Publicado: (2021)

Effect of electro-acupuncture on ovarian expression of α (1)- and β (2)-adrenoceptors, and p75 neurotrophin receptors in rats with steroid-induced polycystic ovaries
por: Manni, Luigi, et al.
Publicado: (2005)

Circulating Linoleic Acid is Associated with Improved Glucose Tolerance in Women after Gestational Diabetes
por: Andersson-Hall, Ulrika, et al.
Publicado: (2018)

Testosterone is an endogenous regulator of BAFF and splenic B cell number
por: Wilhelmson, Anna S., et al.
Publicado: (2018)

Prevalence of HIV-1 pretreatment drug resistance among treatment naïve pregnant women in Bissau, Guinea Bissau
por: Wilhelmson, Sten, et al.
Publicado: (2018)

Prognostic significance of diabetes mellitus and dyslipidemia in men receiving androgen-deprivation therapy for metastatic prostate cancer
por: Hirata, Yu, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_djrgjg4m3ufslq5rfda2ff13sg