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Deciphering Signaling Pathway Networks to Understand the Molecular Mechanisms of Metformin Action

A drug exerts its effects typically through a signal transduction cascade, which is non-linear and involves intertwined networks of multiple signaling pathways. Construction of such a signaling pathway network (SPNetwork) can enable identification of novel drug targets and deep understanding of drug...

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Detalles Bibliográficos
Autores principales: Sun, Jingchun, Zhao, Min, Jia, Peilin, Wang, Lily, Wu, Yonghui, Iverson, Carissa, Zhou, Yubo, Bowton, Erica, Roden, Dan M., Denny, Joshua C., Aldrich, Melinda C., Xu, Hua, Zhao, Zhongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470683/
https://www.ncbi.nlm.nih.gov/pubmed/26083494
http://dx.doi.org/10.1371/journal.pcbi.1004202