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The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Na(v)1.3 Opening
We identified Tf2, the first β-scorpion toxin from the venom of the Brazilian scorpion Tityus fasciolatus. Tf2 is identical to Tb2-II found in Tityus bahiensis. We found that Tf2 selectively activates human (h)Na(v)1.3, a neuronal voltage-gated sodium (Na(v)) subtype implicated in epilepsy and nocic...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470819/ https://www.ncbi.nlm.nih.gov/pubmed/26083731 http://dx.doi.org/10.1371/journal.pone.0128578 |