The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Na(v)1.3 Opening

We identified Tf2, the first β-scorpion toxin from the venom of the Brazilian scorpion Tityus fasciolatus. Tf2 is identical to Tb2-II found in Tityus bahiensis. We found that Tf2 selectively activates human (h)Na(v)1.3, a neuronal voltage-gated sodium (Na(v)) subtype implicated in epilepsy and nocic...

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Detalles Bibliográficos
Autores principales: Camargos, Thalita S., Bosmans, Frank, Rego, Solange C., Mourão, Caroline B. F., Schwartz, Elisabeth F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470819/
https://www.ncbi.nlm.nih.gov/pubmed/26083731
http://dx.doi.org/10.1371/journal.pone.0128578
Descripción
Sumario:We identified Tf2, the first β-scorpion toxin from the venom of the Brazilian scorpion Tityus fasciolatus. Tf2 is identical to Tb2-II found in Tityus bahiensis. We found that Tf2 selectively activates human (h)Na(v)1.3, a neuronal voltage-gated sodium (Na(v)) subtype implicated in epilepsy and nociception. Tf2 shifts hNa(v)1.3 activation voltage to more negative values, thereby opening the channel at resting membrane potentials. Seven other tested mammalian Na(v) channels (Na(v)1.1-1.2; Na(v)1.4-1.8) expressed in Xenopus oocytes are insensitive upon application of 1 μM Tf2. Therefore, the identification of Tf2 represents a unique addition to the repertoire of animal toxins that can be used to investigate Na(v) channel function.

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