Distinct Phenotypes Caused by Mutation of MSH2 in Trypanosome Insect and Mammalian Life Cycle Forms Are Associated with Parasite Adaptation to Oxidative Stress

BACKGROUND: DNA repair mechanisms are crucial for maintenance of the genome in all organisms, including parasites where successful infection is dependent both on genomic stability and sequence variation. MSH2 is an early acting, central component of the Mismatch Repair (MMR) pathway, which is respon...

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Detalles Bibliográficos
Autores principales: Grazielle-Silva, Viviane, Zeb, Tehseen Fatima, Bolderson, Jason, Campos, Priscila C., Miranda, Julia B., Alves, Ceres L., Machado, Carlos R., McCulloch, Richard, Teixeira, Santuza M. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470938/
https://www.ncbi.nlm.nih.gov/pubmed/26083967
http://dx.doi.org/10.1371/journal.pntd.0003870

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470938/
https://www.ncbi.nlm.nih.gov/pubmed/26083967
http://dx.doi.org/10.1371/journal.pntd.0003870

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