The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study

Fibroblast growth factor receptors (FGFRs) are recognized therapeutic targets in cancer. We here describe insights underpinning the impact of mutations on FGFR1 and FGFR3 kinase activity and drug efficacy, using a combination of computational calculations and experimental approaches including cellul...

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Detalles Bibliográficos
Autores principales: Bunney, Tom D., Wan, Shunzhou, Thiyagarajan, Nethaji, Sutto, Ludovico, Williams, Sarah V., Ashford, Paul, Koss, Hans, Knowles, Margaret A., Gervasio, Francesco L., Coveney, Peter V., Katan, Matilda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471147/
https://www.ncbi.nlm.nih.gov/pubmed/26097890
http://dx.doi.org/10.1016/j.ebiom.2015.02.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471147/
https://www.ncbi.nlm.nih.gov/pubmed/26097890
http://dx.doi.org/10.1016/j.ebiom.2015.02.009

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