SUMOylation Blocks the Ubiquitin-Mediated Degradation of the Nephronophthisis Gene Product Glis2/NPHP7

Glis2/NPHP7 is a transcriptional regulator mutated in type 7 nephronophthisis, an autosomal recessive ciliopathy associated with cystic and fibrotic kidney disease as well as characteristic extrarenal manifestations. While most ciliopathy-associated molecules are found in the cilium, Glis2/NPHP7 pre...

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Detalles Bibliográficos
Autores principales: Ramachandran, Haribaskar, Herfurth, Konstantin, Grosschedl, Rudolf, Schäfer, Tobias, Walz, Gerd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471195/
https://www.ncbi.nlm.nih.gov/pubmed/26083374
http://dx.doi.org/10.1371/journal.pone.0130275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471195/
https://www.ncbi.nlm.nih.gov/pubmed/26083374
http://dx.doi.org/10.1371/journal.pone.0130275

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