TrkB reduction exacerbates Alzheimer's disease-like signaling aberrations and memory deficits without affecting β-amyloidosis in 5XFAD mice

Accumulating evidence shows that brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B (TrkB) significantly decrease early in Alzheimer's disease (AD). However, it remains unclear whether BDNF/TrkB reductions may be mechanistically involved in the pathogenesis o...

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Detalles Bibliográficos
Autores principales: Devi, L, Ohno, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471286/
https://www.ncbi.nlm.nih.gov/pubmed/25942043
http://dx.doi.org/10.1038/tp.2015.55

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471286/
https://www.ncbi.nlm.nih.gov/pubmed/25942043
http://dx.doi.org/10.1038/tp.2015.55

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