Methotrexate Promotes Platelet Apoptosis via JNK-Mediated Mitochondrial Damage: Alleviation by N-Acetylcysteine and N-Acetylcysteine Amide

Thrombocytopenia in methotrexate (MTX)-treated cancer and rheumatoid arthritis (RA) patients connotes the interference of MTX with platelets. Hence, it seemed appealing to appraise the effect of MTX on platelets. Thereby, the mechanism of action of MTX on platelets was dissected. MTX (10 μM) induced...

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Detalles Bibliográficos
Autores principales: Paul, Manoj, Hemshekhar, Mahadevappa, Thushara, Ram M., Sundaram, Mahalingam S., NaveenKumar, Somanathapura K., Naveen, Shivanna, Devaraja, Sannaningaiah, Somyajit, Kumar, West, Robert, Basappa, Nayaka, Siddaiah C., Zakai, Uzma I., Nagaraju, Ganesh, Rangappa, Kanchugarakoppal S., Kemparaju, Kempaiah, Girish, Kesturu S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471342/
https://www.ncbi.nlm.nih.gov/pubmed/26083398
http://dx.doi.org/10.1371/journal.pone.0127558

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471342/
https://www.ncbi.nlm.nih.gov/pubmed/26083398
http://dx.doi.org/10.1371/journal.pone.0127558

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