Macrodiolide Formation by the Thioesterase of a Modular Polyketide Synthase**

Mostrar otras versiones (1)

Elaiophylin is an unusual C(2)-symmetric antibiotic macrodiolide produced on a bacterial modular polyketide synthase assembly line. To probe the mechanism and selectivity of diolide formation, we sought to reconstitute ring formation in vitro by using a non-natural substrate. Incubation of recombina...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Yongjun, Prediger, Patrícia, Dias, Luiz Carlos, Murphy, Annabel C, Leadlay, Peter F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471547/
https://www.ncbi.nlm.nih.gov/pubmed/25753953
http://dx.doi.org/10.1002/anie.201500401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471547/
https://www.ncbi.nlm.nih.gov/pubmed/25753953
http://dx.doi.org/10.1002/anie.201500401

Ejemplares similares