Cargando…

Macrodiolide Formation by the Thioesterase of a Modular Polyketide Synthase**

Mostrar otras versiones (1)

Elaiophylin is an unusual C(2)-symmetric antibiotic macrodiolide produced on a bacterial modular polyketide synthase assembly line. To probe the mechanism and selectivity of diolide formation, we sought to reconstitute ring formation in vitro by using a non-natural substrate. Incubation of recombina...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Yongjun, Prediger, Patrícia, Dias, Luiz Carlos, Murphy, Annabel C, Leadlay, Peter F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2015
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471547/ https://www.ncbi.nlm.nih.gov/pubmed/25753953 http://dx.doi.org/10.1002/anie.201500401

Ejemplares similares

Macrodiolide Formation by the Thioesterase of a Modular Polyketide Synthase**
por: Zhou, Yongjun, et al.
Publicado: (2015)

Iterative Mechanism of Macrodiolide Formation in the Anticancer Compound Conglobatin
por: Zhou, Yongjun, et al.
Publicado: (2015)

Multiple Functions of the Type II Thioesterase Associated with the Phoslactomycin Polyketide Synthase
por: Geyer, Kyra, et al.
Publicado: (2022)

Evidence for an iterative module in chain elongation on the azalomycin polyketide synthase
por: Hong, Hui, et al.
Publicado: (2016)

The Stereochemistry of Complex Polyketide Biosynthesis by Modular Polyketide Synthases
por: Kwan, David H., et al.
Publicado: (2011)

Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity
por: Green, Simon R., et al.
Publicado: (2023)

Traffic Control in Modular Polyketide Synthases
por: Finzel, Kara, et al.
Publicado: (2016)

Structure of a modular polyketide synthase
por: Dutta, Somnath, et al.
Publicado: (2014)

An Iterative Module in the Azalomycin F Polyketide Synthase Contains a Switchable Enoylreductase Domain
por: Xu, Wei, et al.
Publicado: (2017)

ASMPKS: an analysis system for modular polyketide synthases
por: Tae, Hongseok, et al.
Publicado: (2007)

An in vitro platform for engineering and harnessing modular polyketide synthases
por: Miyazawa, Takeshi, et al.
Publicado: (2020)

A Polyketide Synthase Component for Oxygen Insertion into Polyketide Backbones
por: Meoded, Roy A., et al.
Publicado: (2018)

Chemical Probes for the Functionalization of Polyketide Intermediates**
por: Riva, Elena, et al.
Publicado: (2014)

An Alkyne‐Metathesis‐Based Approach to the Synthesis of the Anti‐Malarial Macrodiolide Samroiyotmycin A
por: Yiannakas, Ektoras, et al.
Publicado: (2021)

An integrated computational approach towards novel drugs discovery against polyketide synthase 13 thioesterase domain of Mycobacterium tuberculosis
por: Altharawi, Ali, et al.
Publicado: (2023)

Offloading Role of a Discrete Thioesterase in Type II Polyketide Biosynthesis
por: Hua, Kangmin, et al.
Publicado: (2020)

Assembly line termination in cylindrocyclophane biosynthesis: discovery of an editing type II thioesterase domain in a type I polyketide synthase
por: Nakamura, H., et al.
Publicado: (2015)

Diene Incorporation by a Dehydratase Domain Variant in Modular Polyketide Synthases
por: Hobson, Christian, et al.
Publicado: (2022)

Catalytic enantioselective synthesis of macrodiolides and their application in chiral recognition
por: Xiao, Wanlong, et al.
Publicado: (2020)

The Cell Wall-Associated Mycolactone Polyketide Synthases Are Necessary but Not Sufficient for Mycolactone Biosynthesis
por: Porter, Jessica L., et al.
Publicado: (2013)

Engineering the stambomycin modular polyketide synthase yields 37-membered mini-stambomycins
por: Su, Li, et al.
Publicado: (2022)

Engineering Aspergillus oryzae for the Heterologous Expression of a Bacterial Modular Polyketide Synthase
por: Feng, Jin, et al.
Publicado: (2021)

Expanding Extender Substrate Selection for Unnatural Polyketide Biosynthesis by Acyltransferase Domain Exchange within a Modular Polyketide Synthase
por: Englund, Elias, et al.
Publicado: (2023)

ClusterCAD: a computational platform for type I modular polyketide synthase design
por: Eng, Clara H, et al.
Publicado: (2018)

Emulating evolutionary processes to morph aureothin-type modular polyketide synthases and associated oxygenases
por: Peng, Huiyun, et al.
Publicado: (2019)

Repurposing Modular Polyketide Synthases and Non-ribosomal Peptide Synthetases for Novel Chemical Biosynthesis
por: Hwang, Soonkyu, et al.
Publicado: (2020)

Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acyltransferase
por: Kalkreuter, Edward, et al.
Publicado: (2021)

C–N bond formation by a polyketide synthase
por: Wang, Jialiang, et al.
Publicado: (2023)

A Modular In Vitro Platform for the Production of Terpenes and Polyketides from CO(2)
por: Sundaram, Srividhya, et al.
Publicado: (2021)

Structural Basis for the Activity and Substrate Specificity of Fluoroacetyl-CoA Thioesterase FlK
por: Dias, Marcio V. B., et al.
Publicado: (2010)

Insights into azalomycin F assembly-line contribute to evolution-guided polyketide synthase engineering and identification of intermodular recognition
por: Zhai, Guifa, et al.
Publicado: (2023)

Engineering Polyketide Synthases
por: Katz, Leonard
Publicado: (2002)

Mechanism of Orlistat Hydrolysis by the Thioesterase of Human Fatty Acid Synthase
por: Fako, Valerie E., et al.
Publicado: (2014)

Dissecting how modular polyketide synthase ketoreductases interact with acyl carrier protein-attached substrates
por: Moretto, Luisa, et al.
Publicado: (2017)

Protein‐Protein Recognition Involved in the Intermodular Transacylation Reaction in Modular Polyketide Synthase in the Biosynthesis of Vicenistatin
por: Chisuga, Taichi, et al.
Publicado: (2022)

Author Correction: Engineering the stambomycin modular polyketide synthase yields 37-membered mini-stambomycins
por: Su, Li, et al.
Publicado: (2022)

Polyketide genes in the marine sponge Plakortis simplex: a new group of mono-modular type I polyketide synthases from sponge symbionts
por: Della Sala, Gerardo, et al.
Publicado: (2013)

The biosynthetic pathway to ossamycin, a macrocyclic polyketide bearing a spiroacetal moiety
por: Bilyk, Oksana, et al.
Publicado: (2019)

Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria
por: Hong, Hui, et al.
Publicado: (2008)

Site directed mutagenesis as a precision tool to enable synthetic biology with engineered modular polyketide synthases
por: Drufva, Erin E., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_p0gi34ti8lmrtbks8pmst1o4s4