Nanomolar Inhibitors of the Transcription Factor STAT5b with High Selectivity over STAT5a**

Src homology 2 (SH2) domains play a central role in signal transduction. Although many SH2 domains have been validated as drug targets, their structural similarity makes development of specific inhibitors difficult. The cancer-relevant transcription factors STAT5a and STAT5b are particularly challen...

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Detalles Bibliográficos
Autores principales: Elumalai, Nagarajan, Berg, Angela, Natarajan, Kalaiselvi, Scharow, Andrej, Berg, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471549/
https://www.ncbi.nlm.nih.gov/pubmed/25702814
http://dx.doi.org/10.1002/anie.201410672

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471549/
https://www.ncbi.nlm.nih.gov/pubmed/25702814
http://dx.doi.org/10.1002/anie.201410672

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