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Nanomolar Inhibitors of the Transcription Factor STAT5b with High Selectivity over STAT5a**
Src homology 2 (SH2) domains play a central role in signal transduction. Although many SH2 domains have been validated as drug targets, their structural similarity makes development of specific inhibitors difficult. The cancer-relevant transcription factors STAT5a and STAT5b are particularly challen...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
WILEY-VCH Verlag
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471549/ https://www.ncbi.nlm.nih.gov/pubmed/25702814 http://dx.doi.org/10.1002/anie.201410672 |