Discovery and Reconstitution of the Cycloclavine Biosynthetic Pathway—Enzymatic Formation of a Cyclopropyl Group**

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The ergot alkaloids, a class of fungal-derived natural products with important biological activities, are derived from a common intermediate, chanoclavine-I, which is elaborated into a set of diverse structures. Herein we report the discovery of the biosynthetic pathway of cycloclavine, a complex er...

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Detalles Bibliográficos
Autores principales: Jakubczyk, Dorota, Caputi, Lorenzo, Hatsch, Anaëlle, Nielsen, Curt A F, Diefenbacher, Melanie, Klein, Jens, Molt, Andrea, Schröder, Hartwig, Cheng, Johnathan Z, Naesby, Michael, O'Connor, Sarah E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471609/
https://www.ncbi.nlm.nih.gov/pubmed/25712404
http://dx.doi.org/10.1002/anie.201410002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471609/
https://www.ncbi.nlm.nih.gov/pubmed/25712404
http://dx.doi.org/10.1002/anie.201410002

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