Antitumor activity of the MEK inhibitor trametinib on intestinal polyp formation in Apc(Δ716) mice involves stromal COX-2

Extracellular signal-regulated kinase is an MAPK that is most closely associated with cell proliferation, and the MEK/ERK signaling pathway is implicated in various human cancers. Although epidermal growth factor receptor, KRAS, and BRAF are considered major targets for colon cancer treatment, the p...

Descripción completa

Detalles Bibliográficos
Autores principales: Fujishita, Teruaki, Kajino-Sakamoto, Rie, Kojima, Yasushi, Taketo, Makoto Mark, Aoki, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471789/
https://www.ncbi.nlm.nih.gov/pubmed/25855137
http://dx.doi.org/10.1111/cas.12670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471789/
https://www.ncbi.nlm.nih.gov/pubmed/25855137
http://dx.doi.org/10.1111/cas.12670

Ejemplares similares