Impact of autoimmune risk alleles on the immune system

Genetic analyses of autoimmune diseases have revealed hundreds of disease-associated DNA variants, but the identity and function of the causal variants are understudied and warrant deeper mechanistic studies. Here, we highlight methods for deciphering how alleles that are associated with autoimmune...

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Detalles Bibliográficos
Autores principales: Ray, John P, Hacohen, Nir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471922/
https://www.ncbi.nlm.nih.gov/pubmed/26089985
http://dx.doi.org/10.1186/s13073-015-0182-y
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author Ray, John P
Hacohen, Nir
author_facet Ray, John P
Hacohen, Nir
author_sort Ray, John P
collection PubMed
description Genetic analyses of autoimmune diseases have revealed hundreds of disease-associated DNA variants, but the identity and function of the causal variants are understudied and warrant deeper mechanistic studies. Here, we highlight methods for deciphering how alleles that are associated with autoimmune disease alter the human immune system, and suggest strategies for future autoimmune genetic research.
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spelling pubmed-44719222015-06-19 Impact of autoimmune risk alleles on the immune system Ray, John P Hacohen, Nir Genome Med Comment Genetic analyses of autoimmune diseases have revealed hundreds of disease-associated DNA variants, but the identity and function of the causal variants are understudied and warrant deeper mechanistic studies. Here, we highlight methods for deciphering how alleles that are associated with autoimmune disease alter the human immune system, and suggest strategies for future autoimmune genetic research. BioMed Central 2015-06-19 /pmc/articles/PMC4471922/ /pubmed/26089985 http://dx.doi.org/10.1186/s13073-015-0182-y Text en © Ray and Hacohen. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Comment
Ray, John P
Hacohen, Nir
Impact of autoimmune risk alleles on the immune system
title Impact of autoimmune risk alleles on the immune system
title_full Impact of autoimmune risk alleles on the immune system
title_fullStr Impact of autoimmune risk alleles on the immune system
title_full_unstemmed Impact of autoimmune risk alleles on the immune system
title_short Impact of autoimmune risk alleles on the immune system
title_sort impact of autoimmune risk alleles on the immune system
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471922/
https://www.ncbi.nlm.nih.gov/pubmed/26089985
http://dx.doi.org/10.1186/s13073-015-0182-y
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