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Notch Transmembrane Domain: Secondary Structure and Topology
[Image: see text] The Notch signaling pathway is critical in development, neuronal maintenance, and hematopoiesis. An obligate step in the activation of this pathway is cleavage of its transmembrane (TM) domain by γ-secretase. While the soluble domains have been extensively studied, little has been...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472088/ https://www.ncbi.nlm.nih.gov/pubmed/26023825 http://dx.doi.org/10.1021/acs.biochem.5b00456 |