Cargando…

Alternative divalent cations (Zn(2+), Co(2+), and Mn(2+)) are not mutagenic at conditions optimal for HIV-1 reverse transcriptase activity

BACKGROUND: Fidelity of DNA polymerases can be influenced by cation co-factors. Physiologically, Mg(2+) is used as a co-factor by HIV reverse transcriptase (RT) to perform catalysis; however, alternative cations including Mn(2+), Co(2+), and Zn(2+) can also support catalysis. Although Zn(2+) support...

Descripción completa

Detalles Bibliográficos
Autores principales: Achuthan, Vasudevan, DeStefano, Jeffrey J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472245/
https://www.ncbi.nlm.nih.gov/pubmed/25934642
http://dx.doi.org/10.1186/s12858-015-0041-x