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Mitochondrial Dysfunction Induced by N-Butyl-1-(4-Dimethylamino)Phenyl-1,2,3,4-Tetrahydro-β-Carboline-3-Carboxamide Is Required for Cell Death of Trypanosoma cruzi
BACKGROUND: Chagas’ disease is caused by the protozoan Trypanosoma cruzi and affects thousands of people worldwide. The available treatments are unsatisfactory, and new drugs must be developed. Our group recently reported the trypanocidal activity of the synthetic compound N-butyl-1-(4-dimethylamino...
Autores principales: | Volpato, Hélito, Desoti, Vânia Cristina, Valdez, Rodrigo Hinojosa, Ueda-Nakamura, Tânia, Silva, Sueli de Oliveira, Sarragiotto, Maria Helena, Nakamura, Celso Vataru |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472351/ https://www.ncbi.nlm.nih.gov/pubmed/26086449 http://dx.doi.org/10.1371/journal.pone.0130652 |
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